What is the maximum dose of Diphenhydramine that can be given in a 4-hour period for a patient with a moderate/severe allergic reaction?

The correct maximum dose of Diphenhydramine that can be administered in a 4-hour period for a patient with a moderate/severe allergic reaction is 50 mg. This dosage is in accordance with established guidelines and protocols for managing allergic reactions, where Diphenhydramine is utilized for its antihistaminic properties.

In adults, the typical dosing for oral or intravenous administration often allows for 25 to 50 mg per dose, with the option to repeat this dosing after a certain time frame, usually up to every 4 to 6 hours as needed, but not exceeding a total limit within a given timeframe. The choice of 50 mg reflects the maximum amount used in a single administration within that period, which is adequate to effectively address the symptomatic treatment of allergic reactions while maintaining safety.

Higher doses may lead to increased side effects, such as sedation or anticholinergic effects, and careful consideration is given to avoid exceeding recommended guidelines to ensure patient safety. This makes 50 mg the appropriate choice to balance efficacy and safety in treating moderate to severe allergic reactions.